The Chrysler Corporation has used the designation Chrysler 300C to refer to two different vehicles, which are described in separate articles.

• The 1957 Chrysler 300C, that year's version of the Chrysler 300 "letter series"; a large, high-performance luxury coupe sold in very limited numbers.
• The 2005 model year Chrysler 300C, launched in 2004, the top-of-the-line Chrysler 300.